SD-Acne Study

David Margolis

Given the influence of hormones on sebum production, therapies that address underlying hormonal factors, such as spironolactone, represent potentially underutilized treatment options for women with acne and could help decrease the use of long-term oral antibiotics in this patient population.
To determine whether spironolactone is non-inferior to the oral tetracycline-class antibiotic doxycycline hyclate for the treatment of acne in women, we are conducting the SD-Acne Study, a randomized, double-blind, multi-center comparative effectiveness study with patients aged 16-40 who have moderate to severe acne.