{"id":733,"date":"2021-09-07T15:24:17","date_gmt":"2021-09-07T15:24:17","guid":{"rendered":"https:\/\/dermatology.upenn.edu\/training-new\/?p=733"},"modified":"2023-05-05T16:25:18","modified_gmt":"2023-05-05T16:25:18","slug":"current-t32-trainee-go-postdoc","status":"publish","type":"post","link":"https:\/\/dermatology.upenn.edu\/training\/2021\/09\/07\/current-t32-trainee-go-postdoc\/","title":{"rendered":"T32 Postdoctoral Fellow: Christina Go, PhD"},"content":{"rendered":"<div id='av_section_1'  class='avia-section main_color avia-section-default avia-no-border-styling  avia-bg-style-scroll  avia-builder-el-0  avia-builder-el-no-sibling   container_wrap fullsize' style='background-color: #ffffff;  '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-733'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_two_fifth  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_one_half  avia-builder-el-first  \" style='border-radius:0px; '><p><div  class='avia-image-container  av-styling-    avia-builder-el-2  el_before_av_image  avia-builder-el-first  avia-align-left '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" class='wp-image-730 avia-img-lazy-loading-not-730 avia_image' src=\"https:\/\/dermatology.upenn.edu\/training\/wp-content\/uploads\/sites\/13\/2021\/09\/Go-Christina_Headshot-small-200x300.jpg\" alt='' title='Go, Christina_Headshot small' height=\"300\" width=\"200\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong>Christina K. Go, PhD<\/strong><\/h3>\n<p><strong>Appointment:<\/strong><\/p>\n<p>T32 Postdoctoral Fellow, 2020-2022<\/p>\n<p><strong>Mentor:\u00a0 <\/strong>Phillip Scott, PhD<\/p>\n<p><strong>Project: <\/strong> Inflammasome activation in cutaneous leishmaniasis<\/p>\n<p><span style=\"color: #0000ff\"><a style=\"color: #0000ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/collections\/59070005\/\"><br \/>\nPublications Link <\/a><\/span><\/p>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-5  el_after_av_two_fifth  avia-builder-el-last  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h5><strong>Biography:<\/strong><\/h5>\n<p>Christina earned her Ph.D. in Biomedical Sciences from the Lewis Katz School of Medicine at Temple University in 2018. Her studies characterized the role of a scaffolding protein, Partner of STIM1, in coordinating cytoplasmic Ca<sup>2+<\/sup> influx and efflux during T cell activation. She subsequently joined the lab of Dr. Phillip Scott in the Department of Pathobiology at PennVet studying cutaneous leishmaniasis, a neglected tropical disease characterized by chronic, ulcerated lesions due to high parasite burden or immunopathology. Gene expression studies in patients and murine models have demonstrated that immunopathology is driven by cytolytic T cells and subsequent processing and release of pro-inflammatory IL-1\u03b2 by the NLRP3 inflammasome. Christina\u2019s studies focus on understanding the mechanisms of IL-1\u03b2 release in severe disease. To this end, she has established <em>in vitro<\/em> co-culture systems to investigate what signals activate the inflammasome during T cell-mediated cytolysis. Additionally, she is using a fluorescent inflammasome reporter mouse to identify the cell types involved in aberrant inflammasome activation and IL-1\u03b2 release <em>in vivo<\/em>. These studies will provide novel therapeutic strategies to target immunopathologic responses in cutaneous leishmaniasis.<\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":77,"featured_media":730,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[55,58],"tags":[],"class_list":["post-733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alumni-t32-trainee","category-postdoc-alumni"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - 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