About the Lab:

Interests of the Allman lab include: (a) Long-lived plasma cells in immunity and autoimmunity. (b) Metabolic regulation of B-lineage effector fates. The Allman lab discovered that rapamycin, an inhibitor of the metabolic regulatory mTORC1 kinase complex, selectively depletes germinal center and activated B cells when administered to previously immunized mice. They use genetic approaches to define the role of mTORC1 components in germinal center B cell differentiation and survival. Strategies to deplete activated B cells selectively may prove useful in many clinical settings including in autoimmune diseases such as pemphigus.

Training Information:

Current and previous trainees have been highly productive and several of Dr. Allman’s prior trainees are now postdoctoral researchers in basic or applied areas of immunology.