Hydar Ali, PhD
Associate Dean of Faculty Diversity and Mentorship
Department of Basic & Translational Sciences
School of Dental Medicine
About the Lab:
The Ali lab studies the role of G protein coupled receptor (GPCR) signaling in human mast cells. They recently identified MRGPRX2 as a novel GPCR that is predominantly expressed on human skin mast cells but no other immune or structural cells. The current focus of studies in the lab are to: (a) to identify the structural components of MRGPRX2 that interacts with multiple ligands and G proteins to induce mast cell degranulation, (b) to determine the roles of Ca2+ channels, granule-associated MRGPRX2, lipid rafts, autophagy proteins on mast cell degranulation and (c) to modulate pseudo-allergic skin reactions and experimental rosacea by targeting MRGPRX2 signaling in human mast cells. The Ali lab is funded by two NIH grants for this particular project.
Dr. Ali has trained many successful predoctoral and postdoctoral students and provides training related to skin mast cells, inflammation, and host defense.