Matthew L. Hedberg, MD, PHD 


Instructor and Postdoctoral Fellow, 2021 – Present

2+2 Program

Mentor:  John T. Seykora, MD, PhD

Project:  Interrogation of immune editing and immunosurveillance in the carcinogenesis of cutaneous squamous cell carcinoma. 

Publications Link



Dr. Hedberg received his BA in chemistry with departmental honors and a research scholar designation from the University of Utah. Where he developed transgenic mouse models of translocation-associated sarcomas with Nobel laureate, Dr. Mario Capecchi. He received his MD and his PhD through the medical scientist training program at the University of Pittsburgh School of Medicine. Where he secured a Ruth L. Kirschstein National Research Service Award F30 grant. His dissertation advanced personalized medicine in head and neck squamous cell carcinoma by defining the genetic landscape of HNSCC and helping to develop therapeutic approaches based on genetic alterations in patient tumors. He completed an anatomic pathology residency at Washington University School of Medicine in St. Louis and a dermatopathology fellowship at the Perelman School of Medicine at the University of Pennsylvania. Dr. Hedberg’s clinical and research interests include cutaneous oncology, immunology and dermatopathology. Dr. Hedberg evaluates dermatopathology specimens at the Hospital of the University of Pennsylvania, while also conducting basic science research in immune editing and immunosurveillance in cutaneous squamous cell carcinoma in situ; with the goal of developing immunomodulatory chemoprophylaxis. Dr. Hedberg is a Waine C. Johnson Endowed Research Fellow of Dermatopathology.

T32-Funded research supported the following: 


Research Grant, Dermatology Foundation, 2021-2022