Biography:

Dr. Hedberg received his BA in chemistry with departmental honors and a research scholar designation from the University of Utah. Where he developed transgenic mouse models of translocation-associated sarcomas with Nobel laureate, Dr. Mario Capecchi. He received his MD and his PhD through the medical scientist training program at the University of Pittsburgh School of Medicine. Where he secured a Ruth L. Kirschstein National Research Service Award F30 grant. His dissertation advanced personalized medicine in head and neck squamous cell carcinoma by defining the genetic landscape of HNSCC and helping to develop therapeutic approaches based on genetic alterations in patient tumors. He completed an anatomic pathology residency at Washington University School of Medicine in St. Louis and a dermatopathology fellowship at the Perelman School of Medicine at the University of Pennsylvania. Dr. Hedberg’s clinical and research interests include cutaneous oncology, immunology and dermatopathology. Dr. Hedberg evaluates dermatopathology specimens at the Hospital of the University of Pennsylvania, while also conducting basic science research in immune editing and immunosurveillance in cutaneous squamous cell carcinoma in situ; with the goal of developing immunomodulatory chemoprophylaxis. Dr. Hedberg is a Waine C. Johnson Endowed Research Fellow of Dermatopathology.

T32-Funded research supported the following: 

Publications:

Roche FC, Hedberg ML, Fischer AS, Ray A, Dentchev T, Rice X, Taylor SC, Seykora JT. Activation of STAT3 in Lymphocytes associated with Central Centrifugal Cicatricial Alopecia. J Am Acad Dermatol. 2023 Feb 20;. doi: 10.1016/j.jaad.2023.01.045. [Epub ahead of print] PubMed PMID: 36813135.

Sprow G, Afarideh M, Dan J, Hedberg ML, Werth VP. Bullous systemic lupus erythematosus in females. Int J Womens Dermatol. 2022 Oct;8(3):e034. doi: 10.1097/JW9.0000000000000034. eCollection 2022 Oct. Review. PubMed PMID: 35923586; PubMed Central PMCID: PMC9324630.

Modi MB, Pei S, Hedberg ML, Fischer AS, Guerrero J, Carreon CK, Cooper K, Seykora JT. Clinical, pathologic, and molecular analyses of superficial low-grade fibromyxoid sarcoma in two young patients: A rare and deceptive mimic of benignancy. J Cutan Pathol. 2022 Jul;49(7):638-644. doi: 10.1111/cup.14215. Epub 2022 Mar 6. PubMed PMID: 35191077; PubMed Central PMCID: PMC9232983.

Hedberg ML, Berry CT, Moshiri AS, Xiang Y, Yeh CJ, Attilasoy C, Capell BC, Seykora JT. Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma. Int J Mol Sci. 2022 Mar 23;23(7). doi: 10.3390/ijms23073478. Review. PubMed PMID: 35408839; PubMed Central PMCID: PMC8998533.

Ko KI, Merlet JJ, DerGarabedian BP, Zhen H, Suzuki-Horiuchi Y, Hedberg ML, Hu E, Nguyen AT, Prouty S, Alawi F, Walsh MC, Choi Y, Millar SE, Cliff A, Romero J, Garvin MR, Seykora JT, Jacobson D, Graves DT. NF-κB perturbation reveals unique immunomodulatory functions in Prx1+ fibroblasts that promote development of atopic dermatitis. Sci Transl Med. 2022 Feb 2;14(630):eabj0324. doi: 10.1126/scitranslmed.abj0324. Epub 2022 Feb 2. PubMed PMID: 35108061; PubMed Central PMCID: PMC8979241.

Grants:

Dermatopathology Research Career Development Award, Dermatology Foundation, 2023

Research Grant, Dermatology Foundation, 2021-2022